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Best NAD+ Boosters: Review Top Nicotinamide Riboside Supplement Brands

No one can avoid the changes that come with aging. Everyone notices when those first few lines creep along near their eyes and mouth, but they are just the start of major changes to come. If anything, wrinkles are a sign that NAD+ levels might not be exactly what they should be, showing cells dying right in front of the sufferer’s eyes.

Anti-aging supplements are becoming increasingly popular to help with all of the changes that come as the body gets older. Among these many formulas, consumers will find a hidden gem – NAD+ boosters. These anti-aging remedies are growing in popularity every day, helping users to deal with aging within the cells while smoothing the complexion. The main ingredient of these supplements – nicotinamide adenine dinucleotide – can improve the health of cells, speeding up the healing process rapidly. They are known by many names, but they can be found with many major retailers nowadays.

To fully understand the way that these remedies work, keep reading.

Ranking the Top NAD+ Supplements for 2023

With a careful review with the editorial team, this guide narrowed down the best products found anywhere online for NAD+ boosting. The supplements covered in this guide include:

  • Tru Niagen
  • Cymbiotika NMN
  • Elysium
  • RiboGEN
  • Life Extension NAD+ Cell Regenerator
  • NR Chloride Powder
  • Alive By Science
  • Quicksilver Scientific Liposomal NAD+ Gold
  • HPN Supplements NAD3 NAD+ Booster
  • Toniq NMN
  • Lifemode NMN

Let’s discuss what makes each of these formulas so unique.

Tru Niagen

There are few products as well known as Tru Niagen because it offers powerful support for natural cellular energy production. Users can view all of the scientific evidence used to create their formula on the official website.

To encourage cell repair, Tru Niagen contains a total of 500 mg of NR in every capsule, and users only need one to make a difference. Users can choose to get the 300 mg concentration as well if they want a less strong effect. Users have their choice of up to 180 capsules in a single bottle, though they only need 1 capsule a day to make a lasting difference.

The cost of the bottle of Tru Niagen will depend on how many capsules the user orders in one bottle, but it starts at $40.

Cymbiotika NMN

Cymbiotika NMN is another notable formula found on this list, which is why it only ranks in the second place. It improves NAD+ levels with NMN, which is a precursor to NAD+ naturally. Within every capsule, consumers get an assortment of healthy ingredients, including green tea extract, resveratrol, and green coffee bean. All of these ingredients come together to improve nitric oxide production. When using two capsules, users can expect to improve energy levels, protect their body from the typical changes of aging, and support cognitive health.

To get one bottle, Cymbiotika NMN is available for about $77.


Elysium is a huge name in the NAD+ booster industry because it uses B vitamins that are proven to have a positive effect on brain health and performance. The brain atrophies as the body ages, which is why these ingredients are so important to better health. In some studies, using the right combination of B vitamins can help protect the brain from age-related decline.

To add to the B vitamins, consumers will also get omega-3 fatty acids, antioxidants, and anthocyanins. All of these ingredients have impressive bioavailability to survive the digestive system as the capsule breaks down. However, unlike other products, consumers are able to purchase a biological age test kit to see if the anti-aging benefits will help them.

Users can either buy Matter or Basis to help with NAD+ levels, starting at $50.


RiboGEN offers NR in its supplements, and the creators make a rather substantial claim – that they are the only brand that offers the level of NR that is found in clinical studies. This formula follows the same pattern of healing as the ingredients get to work on anti-aging benefits. With this assortment of ingredients, consumers can produce more NAD for increased NAD+ levels. This formula doesn’t mess around with its concentrations, offering 99.5% BR and 0.5% NAM.

With 300 servings per bottle, the RiboGEN remedy is $330.

Life Extension NAD+ Cell Regenerator

Life Extension NAD+ Cell Regenerator is fairly clear in its own name, regarding the effect that this remedy will offer. Like the formulas that preceded it, users will get a 300mg dose of NR, which is combined with a healthy amount of trans-resveratrol to promote increased NAD+ levels.

This formula helps users to support the cells and reduce the risk of fatigue. It also helps users to maintain healthy cellular energy, and the $45 price tag makes it easy for anyone to get ahold of this remedy at a good price. NR Chloride Powder NR Chloride Powder is a highly potent formula that is available in 10-gram gars for $30 each mow. The formula is available as a powder so users can mix it up into a beverage that is easy to swallow. They can also put the remedy into their own capsules, if they don’t want to worry about the taste.

This product stands out amongst competitors because it offers lab reports for every single batch. Even the jar helps users to get the most support possible because it is designed to reduce the effects of the UV rays they absorb, which can cause NAD+ levels to drop. Luckily, consumers get the best concentration of NR possible becau8se there’s not a single filler ingredient found in this entire formula. The total cost of this remedy is $30.

Alive By Science

Alive By Science offers multiple NAD+ boosters, ensuring that users get a little variety that isn’t found with other products on this list. They even provide liposomal gels, which allow users to absorb the nutrients with sublingual delivery of the nutrients. Users also have the choice of powdered supplements if they want to blend it up and prepare the remedy as a drink instead.

Users can purchase these supplements for as little as $50.

Quicksilver Scientific Liposomal NAD+ Gold

Quicksilver Scientific Liposomal NAD+ Gold offers a way to naturally increase NAD levels to help users maintain a healthy balance while improving healthy aging and improved energy. It even boosts the user’s cognition, thanks to the liposomal delivery that users get. By using sublingual delivery, consumers can start to experience the benefits rapidly.

Users will only need two pumps of the liquid to get the benefits through the capillaries found under the tongue. They’ll need to hold the gel in their mouth for about 30 seconds to allow it to absorb before swallowing.

This powerful tincture can be ordered for $60.

HPN Supplements NAD3 NAD+ Booster

NAD3 NAD+ Booster by HPN Supplements is the ultimate solution for consumers who want to revive their youthfulness. With its unique formula, consumers get a proprietary blend of ingredients that offers theacrine, wasabi, and copper nicotinic acid. Users who engage in the NAD3 regimen will improve telomerase activity.

The total cost of the NAD3 formula is $60.

Toniq NMN

Toniq NMN offers an attractive label to go along with its straightforward benefits. In every single bottle, consumers get a serving of 99% pure NMN that will help their body to properly produce NAD+ at the right pace. This high-quality supplement is affordably priced for any user, offering up to 180 capsules in a single bottle. Using this formula every day will help users to naturally improve NAD+ levels like many of the other products in this list.

To get a bottle of Toniq NMN, the total cost is $110.

Liftmode NMN

Liftmode NMN offers 10 grams of NMN with each bottle ordered. Though most of the formulas on this list focus on the support that NR offers, NMN isn’t the same vitamin B3 variant as NR. However, users still get the anti-aging benefits that they achieve when they produce the right levels of NAD+ to keep their energy levels up.

Along with the overall cellular energy benefits, this formula also makes the brain sharper and supports regeneration efforts by the body. One bottle can be purchased from the official website for $68.

Deciding the Rankings of the Top NAD+ Supplements

Finding the best NAD+ booster supplements was no easy task for this guide, especially since every product has the exact same claim – it raises NAD+ levels. However, only a small group of these products actually do what they say. To filter through the many products on the market today, take a look to see what criteria were considered.

Proven Ingredients

The only way that any of these NAD+ boosters can work is if it has the right ingredients, which means that the formulas had to offer NR and/or NMN. Both of these nutrients are precursors to the process that produces NAD+.

Strong Doses

Along with containing the right ingredients, all of these efforts are for nothing if the user doesn’t have enough of the ingredients to make a difference. Weak dosages were not the right match for this list, which is why this guide prioritized potent doses that could realistically work for any user.


When a supplement is transparent about what’s inside, it is easy for consumers to trust it. While some brands offer proprietary formulas that conceal the amount of each ingredient, this guide primarily focused on companies who were completely honest about what’s in them.

Complementary Ingredients

Consumers don’t have to exclusively use NR and NMN to get the support for their NAD+ levels. Instead, there are plenty of ingredients that can further help consumers to get the boost for their NAD+ levels, like turmeric, resveratrol, and others. With the right complementary ingredients, this guide included a few other substances for their NAD+ needs.

Manufacturer Reputation

The reputation of the brand that makes the product is just as important as the transparency that these products have to have. Some brands have been around for years, allowing them to make a solid reputation for themselves in their quality and performance. However, some lesser known brands have products that work just as well, even if they haven’t had the chance to have the same number of years under their belts.

Price & Value

Everyone wants to get a good deal, and this guide managed to find products that have different price tags for every budget. However, the price tag wasn’t the most important part. Any product had to be worth whatever they demanded from customers, ensuring that all users have formulas that they can afford and finally get the NAD+ boost they have been searching for.

Advertised Benefits

While the Food and Drug Administration doesn’t regulate supplements, they do have to abide by certain restrictions about their benefits. The creators need to be honest about what they offer to consumers, ensuring that they aren’t exaggerating claims of certain benefits. Being honest about what the formula can do is the quickest and easiest way for consumers to feel confident in the product they choose.

Human Clinical Trials

With one look online, consumers can easily see the plethora of lab tests involving mice and rats, but finding a human trial is a little harder. Luckily, there are quite a few products on this list that have endured human clinical trials, ensuring that they will help boost NAD+ levels.

Main Benefits of NAD+ Boosters

Taking an NAD+ booster supplement is rather straightforward for many consumers, but the best of these products have certain benefits that overcome the effects of aging.

One of the first issues that consumers face as they get older is the suffering of their memory. Luckily, raising NAD+ can help with the repair of DNA while reducing stress. Consumers often find that introducing more NAD+ production can help with neuronal stress, healing their brain as they can improve recall.

Stimulating Weight Loss

Losing weight with an NAD+ booster isn’t a direct effect, but the high-fat/low carb combo that many products recommend. This type of diet can help consumers manage their weight more effectively. Fat is a necessary nutrient for the brain, but eating the right way ensures that users get the boost their brain needs for clear thinking.

Reversing the Effects of Aging

Reversing the effects of aging is one of the most common reasons that consumers take NAD+ boosters in the first place. Consumers shouldn’t expect that they’ll look and feel like they are 20 years old in one night of sleep, but they can improve the reaction their body has to aging.

Boosting Strength and Endurance

The final benefit that comes with increasing natural NAD+ levels is the ability to improve strength and endurance. NAD+ boosters help with DNA repair, muscle growth, and more because they help users to support aging cells more effectively.

Natural Ways to Boost NAD+ Levels

Even though this guide is filled with the different supplements that consumers can try for their NAD+ boost, the truth is that NAD+ levels can be increased without using any of them. Supplementation is an easy way to get support, but it is hardly the only way.

Restrict Calories

Restricting calories is an easy way to boost NAD+ production, which is shown in several studies. Even a drop in calories of 20% can make a difference.

Try Intermittent Fasting

Much like restricting calories, participating in a diet that involves fasting will inherently reduce the number of calories that consumers take in. With fasting and restricting calories, NAD+ production quickly boosts to promote better longevity and healthy aging.

Protect Yourself in Sunlight

Sunlight can be highly damaging to NAD+ production, which is why the body naturally sends NAD to any site with too much sun exposure. Protecting the skin is quite easy, using sunscreen or UV-blocking clothing that will reduce potential damage.

Engage In HIIT Workouts

High intensity interval training can have a positive effect on everything from NAD+ levels to growth hormones. It helps users to support their mitochondrial health, but it also ensures that the body properly uses NAD+ to ease the appearance and effects of aging.

Follow a Healthy Diet

The need to put healthy food in the body for NAD+ regulation could not be emphasized enough. The body needs the right assortment of vitamins and minerals or it can’t produce the right amount of NAD+.

Best Foods for Boosting NAD+ Levels

Supplementation and improving healthy habits can naturally improve NAD+ levels as users eat a better diet and even restrict the number of calories that they take in. However, they can also use the calories they still eat to introduce foods that will automatically help with NAD+ production, like:

Milk, which contains nicotinamide riboside (NR) and should be consumed daily to make the user feel younger than ever.

Fish, which has multiple compounds that act as precursors for NAD+ in tuna, salmon, and sardines.

Mushrooms, which can reduce the appearance of aging and improve NAD+ levels.

Green vegetables, which have a substantial number of vitamins, minerals, and other nutrients that the body requires to make NAD+ in the first place.

Yeast and whole grains, which are rich in vitamin B3 that isn’t found in processed grains.

Side Effects of NAD+ Boosters

When used properly by healthy adults, NAD+ boosters don’t have any side effects that consumers need to worry about. The body naturally needs to produce NAD+ in the right amounts to stay healthy and reduce the damage that comes with aging.

NAD+ boosters have to include ingredients that are scientifically proven to work in concentrations that cannot exceed what the Food and Drug Administration considers to be safe. Luckily, no one has reported side effects. Still, if the person has any medication or medical condition, they might want to double check with their doctor before starting the regimen.

Best Dosage for NAD+ Boosters

Based on clinical research, the majority of NAD+ booster supplements nowadays contain about 300 mg NR or a comparative amount of NMN. Studies show that this amount can improve NAD+ levels safely without overwhelming it. Still, a dose of even 100 mg could be enough to trigger the right production.

More studies are still being performed on NAD+ boosters to truly understand what consumers need to do to get the most from these types of products.

Scientific Evidence for NAD+ Boosters

The scientific evidence behind NAD+ boosters is fairly limited, but the initial research has shown a positive effect on cell repair. Still, there’s a lot to learn about NAD+ and the ingredients that can improve upon it. In this section, consumers can see what researchers have found to be true of the ways to improve NAD+ levels.

Much of the initial research done on NAD+ has been performed on animals, giving consumers a vague idea of what would happen to them. In an animal study, researchers decided to check to see how mice would be affected by using an NR supplement. The researchers discovered that the group of mice that did not receive the placebo had less damage to their DNA and improved neuroplasticity. They also had less neuronal damage and improved production of new brain cells.

NAD+ boosters can also be good for metabolism. Another mouse-based study discovered that using an NAD+ booster made it possible to improve oxidative metabolism in the right setting. Basically, the mice were provided with a high-fat diet as they combined it with an NAD+ booster. The mice who received the booster for NAD+ levels had more energy and less oxidative damage.

Getting older drastically changes muscle tone because the user’s hormone production no longer supports it. Using an NR supplement is incredibly helpful in the preservation and support of muscles. It even boosts strength. In another study, researchers used rats to test muscle and strength gains, discovering that the rats who received NR supplements had more gains during exercise than the ones who only had a placebo.

Repairing DNA is one of the main reasons that consumers take NAD+ boosters now. While this benefit might seem a little vague, one particular study showed that using an NAD+ precursor supplement had the power to improve and speed up DNA repair so effectively that the tissues between a four-month old mouse and an two-year old mouth were practically indiscernible. Other studies show that using an NAD+ booster can help to activate a sirtuins protein, promoting a longer lifespan.

In a 2020 study, researchers sought to understand the correlation between eating less and naturally increasing NAD+ levels. The study discovered that a reduction of 20% to 30% of the amount of calories that users consume in one day consistently could naturally improve the NAD+ produced by the body.

Even though there are a lot of studies on NAD+ that mainly have used mice or rats instead of humans, that doesn’t mean that researchers have entirely shied away from these types of studies. One study in a publication called Nature Communications discovered that introducing NR via supplementation could positively improve NAD+ levels. It also increased levels of adenine diphosphate.

While all of these changes are often associated with improved NAD+ levels, additional research needs to be done to ensure that consumers can continue to see the improvement in their aging process with NAD+.

Frequently Asked Questions About NAD+ Boosters

What is NAD?

NAD is an abbreviation for nicotinamide adenine dinucleotide. It is primarily involved in cell metabolism, and it is available in two different forms – NAD+ and NADH.

How are NAD, NAD+, and NADH different?

The coenzyme found in all cells that is necessary for cell metabolism is NAD. NAD is found in two forms, which are NAD+ and NADH. NAD+ is used for all functions in the cell, while NADH cannot perform the same process because it is already occupied by electrons.

What does NAD+ do?

NAD+ has an important role in cell metabolism. More notably, it helps with the transition of nutrients into energy, causing the production of adenosine triphosphate (ATP). ATP is used as a source of fuel for the cells, allowing them to both make and exchange energy.

What is ATP?

ATP is an abbreviation for adenosine triphosphate. When consumers increase NAD+ levels, they can help with the transition to ATP.

What are sirtuins?

Sirtuins are a type of protein that can be involved in many processes of the cell. They are crucial to cellular energy, collaborating with NAD+ to support healthy gene expression, DNA repair, mitochondria health, and more.

Why is it difficult to maintain NAD as the body ages?

The only way to keep the cells healthy and energetic is to constantly produce NAD, but it is not made at the same rate when the body gets older.

How do consumers know that their NAD levels are low?

Low NAD levels make it harder for the body to make and utilize ATP, which is why many consumers end up feeling lethargic. Some people lose the ability to maintain the same amount of physical or mental energy, leading to severe fatigue.

How does a NAD supplement help?

According to many scientific studies, supplementing NAD with an oral supplement can help reduce the impact on aging. Many researchers have tested NAD on cell cultures and lab mice, showing that their cells regress to the same state they were at when younger. The NAD supplements currently on the market offer similar effects in humans, taking away the damage age-related stress, cellular stress, and more.

What is a NAD booster?

A NAD booster, or an NAD+ booster, aims to help consumers to improve their NAD production. Since NAD levels drop drastically with age, these supplements focus on reducing the symptoms and effects of low NAD+ levels to promote better cellular energy.

What is nicotinamide riboside (NR)?

Nicotinamide riboside (NR) is an important component to NAD biosynthesis. The only way for the body to produce NAD+ is to use NR, which is why many of these supplements are referred to as NAD+ boosters.

What is nicotinamide mononucleotide (NMN)?

Nicotinamide mononucleotide (NMN) is one of the preceding stages before NAD biosynthesis. The body requires NMN as a way to stimulate NAD+ production for improved cellular energy.

How is an NAD+ booster for NMN different from one for NR?

While both NMN and NAD+ are precursors to the process of synthesizing NAD, NAD+ supplements are still relatively new for consumers. Research is still being pursued to learn about these compounds and their effects.

What can consumers do to naturally improve their NAD levels?

Maintaining a healthy diet and exercise routine is the best way to keep NAD at the right levels, helping to burn through stored fat and achieve a healthy weight. Consumers who eat a diet with a lot of fat but minimal carbs can improve the amount of NAD+ and NADH so the body doesn’t have to go through the same oxidation. Consumers can also use intermittent fasting to promote better NAD levels.

Will engaging in high-intensity interval training increase NAD+?

High-intensity interval training, or HIIT, workouts are helpful in increasing the NAD+ levels in the body naturally. When consumers exercise in this way, even for only a short amount of time, their growth hormone production increases and NAD+ levels rise.

Why isn’t it possible to take an NAD+ supplement with NAD+ in it already?

The majority of NAD+ booster supplements will offer NR or NMN, which are both the precursors that NAD+ needs. The reason that these formulas can’t directly provide users with a heaping serving of NAD+ is because it can’t actually break through the cellular walls that way. Having a single capsule of NAD+ would be impossible to swallow, so users have to turn to NR and NMN supplements instead.

Will taking a niacin help improve NAD+ levels?

Niacin can potentially improve NAD+ levels. Also referred to as nicotinic acid, it is a variation of vitamin B3. It isn’t quite as effective as NR or NMN, but it can improve NAD+ levels.

Can NR have a more drastic impact on NAD+ than NMN?

When researchers studied the impact of NR and NMN, they found that the majority of NAD+ booster supplements turned to NR to get the job done (rather than NMN). Some people believe that NMN is like NAD in the sense of being too big to absorb. However, both are effective.

What side effects occur when taking NAD+ booster?

If the adult using this supplement is currently healthy, they should not experience any side effects when using an NAD+ booster. However, the high amount of niacin in some formulas can make the skin red and irritated. Some consumers even report itching or a burning sensation, but these instances are rare.

What foods can consumers eat to get more NAD+?

Drinking milk or eating fish, mushrooms, or yeast can be helpful in the production of NAD and NAD+ levels safely and naturally.

Can sunlight help or hurt NAD+ production?

Excessive exposure to sunlight can cause NAD+ levels to drop, even though NAD+ is necessary to repair the damage that these UV rays can cause. Consumers can use boosting formulas to help with the repairs necessary after prolonged exposure.

How do NAD+ boosters help consumers?

Most creators of these supplements claim that their products help with muscle strength, stamina, energy production, liver health, immunity, and more. Consumers can also use these supplements to regulate their sleep/wake cycle and support healthy cognition. Most importantly, these formulas improve DNA self-repair.

Why are low NAD levels bad?

When consumers have low NAD levels, they are more susceptible to cardiovascular disease, cell death, weight gain, slower metabolism, and reduced brain function.

How does NAD IV therapy work?

While there are many people who use NAD supplements to increase natural NAD+, other people will use intravenous injections. This guide doesn’t include any injectable versions of NAD, but interested consumers can speak with their doctor about NAD injections, which often are paired with complementary vitamins that they inject.

What is the best NAD+ supplement?

Some of the top products for NAD+ are found in this guide – Niagen, Elysium, and Cymbiotika.

Bottom Line

Nicotinamide adenine dinucleotide (NAD) is a necessary component for balanced energy levels. With regular supplementation of ingredients that stimulate NAD+, consumers can improve levels and keep their body healthy from the inside. Consumers who get enough NAD+ in their day are often associated with better cellular energy, endurance, cognition, and more. Some people even reduce their risk of obesity. All of these supplements work towards the goal of a healthier and more youthful body.

Affiliate Disclosure:

The links contained in this product review may result in a small commission if you opt to purchase the product recommended at no additional cost to you. This goes towards supporting our research and editorial team. Please know we only recommend high-quality products.


Please understand that any advice or guidelines revealed here are not even remotely substitutes for sound medical or financial advice from a licensed healthcare provider or certified financial advisor. Make sure to consult with a professional physician or financial consultant before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary and are not guaranteed as the statements regarding these products have not been evaluated by the Food and Drug Administration or Health Canada. The efficacy of these products has not been confirmed by FDA, or Health Canada approved research. These products are not intended to diagnose, treat, cure or prevent any disease and do not provide any kind of get-rich money scheme. Reviewer is not responsible for pricing inaccuracies. Check product sales page for final prices.