Before this one, Notre Dame hadn't scored more than 24 in a game, and its wins over Michigan, Ball State and Vanderbilt came by a total of 20 points.
The Irish are home for Ball State in what looks like the softest spot on their schedule.
The Colts finally gave their franchise quarterback some extra protection by taking the Notre Dame guard, the highest-rated offensive linemen in the NFL draft, with the sixth overall pick on Thursday night.
Martinas Geben and T.J. Gibbs combined for 35 points.
Notre Dame is now on the bubble, and a big story, when Selection Sunday rolls around.
Matt Farrell scored 22 points for the 10th-seeded Fighting Irish (20-13).
Bonzie Colson scored 19 points in 33 minutes.
Martinas Geben and John Mooney each scored 18 points for the Fighting Irish (15-11, 5-8).
The Irish are home Saturday to Florida State, one of just three games remaining this season at Purcell Pavilion.
Ray Spalding scored a career-high 23 points and grabbed 12 rebounds, as Louisville pulled off an 82-78 double-overtime win over Notre Dame on Tuesday night.