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Best Muscle Builders: Top Muscle Building Booster Supplements to Buy

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If you’re a fitness enthusiast, you may already know about the buzz surrounding pre-workout supplements. These dietary supplements have become increasingly popular among gym-goers, weightlifters, and athletes. They are designed to enhance your workout performance by supporting high-intensity exercise, providing the necessary energy, and focusing on crushing your goals.

This review introduces you to the best supplements for muscle growth, allowing you to witness the changes for yourself.

The Best Muscle-Building Supplements in 2023

Below is our list of the best muscle-building supplements:

  • Pre Lab Pro
  • TestoPrime
  • D-Bal Max
  • XWerks Rise
  • Transparent Labs Mass Gainer
  • CrazyBulk Intensive Pre-Train
  • CrazyBulk Tri-Protein
  • CrazyBulk Ultimate CRN-5
  • HyperGH 14X
  • Cellucor C4 Extreme

Pre Lab Pro

  • Ingredients: Beetroot powder, natural caffeine, L-Theanine, L-Tyrosine, vitamin D3, iron, potassium, vitamin B-complex.
  • Pricing: £39
  • Money-Back Guarantee: 30-day
  • What Sets Pre Lab Pro Apart:
    • Claims to contain the world’s cleanest ingredients label
    • Multiple quality control tests by an independent third party to prevent muscle breakdown
    • No artificial additives to support muscle soreness
    • Pre Lab Pro is legal muscle-building pills
    • Recyclable BPA-free bottles
    • Gluten-free and contains no soy, egg, fish, dairy, peanuts, or other allergens.
    • GMO-free for healthy muscle cells.

Pre Lab Pro is a top-quality pre-workout supplement that comes as a powder. It’s designed to help you power through intense workouts and achieve your fitness goals by providing essential nutrients such as vitamins, minerals, and amino acids.

Unlike other pre-workout supplements, Pre Lab Pro dietary supplements have been meticulously researched and tested to ensure that it delivers consistent results and helps you push your limits beyond what you thought was possible.

Pre Lab Pro protein powder differs from other pre-workout supplements in its ability to provide you with never-ending stamina, insane muscle strength, and laser-like focus. With its unique blend of ingredients, this muscle-building supplement helps reduce muscle fatigue, increase endurance capacity, and aid in muscle recovery, all while speeding up your post-workout recovery.

By taking Pre Lab Pro protein powder before a high-intensity exercise, you’ll feel more energized and ready to tackle any challenge that comes your way.

Benefits Of Pre Lab Pro

Increased energy and focus: Pre Lab Pro muscle supplement contains natural caffeine from Coffea Robusta seeds that will give you the energy and focus you need to power through your workouts without feeling jittery or anxious.

Enhanced muscle growth and strength: By boosting blood flow to your muscles, the Pre Lab Pro muscle builder supplement helps to gain muscle mass and make your muscles stronger and more efficient, allowing them to grow more effectively.

Improved endurance and stamina: With Pre Lab Pro muscle supplement, you’ll be able to push yourself harder and longer during your workouts, thanks to its ability to reduce muscle fatigue and increase endurance capacity.

Faster muscle recovery and reduced muscle damage: Pre Lab Pro muscle growth supplement helps to speed up post-workout recovery, allowing you to get back to your workouts sooner and with less muscle damage.


  • Ingredients: Ashwagandha extract, D-aspartic acid, black pepper extract, fenugreek, garlic extract, green tea extract, Panax ginseng, essential vitamins, zinc.
  • Pricing: $59.99
  • Money-Back Guarantee: 30-day
  • What Sets TestoPrime Apart:
    • FDA-approved ingredients to build muscle
    • Manufactured in GMP registered facility and is GMO-free
    • Vegan and soy-free formula to enhance red blood cell production

Are you struggling with low testosterone levels and the effects it can have on your mood, energy, and muscle growth? If so, it’s time to try TestoPrime, the all-natural testosterone booster that promises to reverse the effects of low testosterone and boost your overall well-being.

TestoPrime is a product of Wolfson Brands (U.K.) Limited, and it has been on the market for about five years. This natural testosterone booster comprises natural ingredients like fenugreek, ginseng, ashwagandha extract, and D-aspartic acid. These ingredients boost testosterone levels while providing various benefits for overall health and fitness.

One of the main benefits of testosterone boosters from TestoPrime is its ability to improve mood and energy and boost muscle growth. By increasing testosterone levels, this dietary supplement can help you feel more motivated and energized during your workouts, leading to better results in terms of muscle growth while avoiding the risks of muscle breakdown.

TestoPrime testosterone boosters can also help you lose weight and build lean muscle mass if you take it alongside regular exercise and weight training. It contains natural ingredients, including fruit extracts and vitamins, and the mixture has no added allergens or additives.

The best part about the TestoPrime muscle growth supplement is that it does not require a prescription and can be easily purchased.

Benefits Of TestoPrime

Can Reduce Stress By Up To 71.6%: The potent blend of natural ingredients in TestoPrime can help your body overcome the adverse effects of cortisol, the hormone responsible for causing stress.

By doing so, this rapid muscle growth enhancer supplement can assist in the elimination of unwanted body fat, allowing you to achieve a leaner and more attractive physique that will make you feel confident and proud to wear clothes you haven’t worn in ages.

May Help Improve Endurance By Up To 92.2%: One of the remarkable benefits of TestoPrime’s muscle gain supplements is the unique blend of natural ingredients and its ability to enhance your VO2 max levels, which refers to your muscle cells’ ability to consume oxygen.

By naturally increasing your VO2 max levels, TestoPrime muscle mass supplements support nitric oxide production, leading to longer-lasting energy levels throughout the day. This sustained energy is ideal for those looking to power through long days at work or intense training sessions at the gym without feeling tired or drained.

With the TestoPrime protein supplement, you can take advantage of the natural benefits of its ingredients to optimize your body’s ability to consume oxygen and enjoy increased energy levels and stamina that help you accomplish your daily tasks with ease.

Burns Overall Body Fat By Up To 16%: TestoPrime muscle-building pills also contain high levels of piperine, a compound found in black pepper, that is proven to activate fat-burning and improve fat loss. This synergistic blend of natural ingredients supports a constant and healthy flow of testosterone, promoting an enhanced fat-loss process.

Can Increase Muscle Strength By Up To 138.7%: D-aspartic acid stimulates the Leydig cells to produce more testosterone and promote muscle growth, fat loss, and overall body strength. TestoPrime’s potent blend of natural ingredients enhances blood circulation, giving your muscles more energy for explosive gains you can feel and visibly see.

D-Bal Max

  • Ingredients: Ashwagandha, copper sulfate, vitamin B9, L-Lysine HCL, caffeine.
  • Pricing: $69.99
  • Money-Back Guarantee: 60-day
  • What Sets D-Bal Max Apart:
    • Safe alternative to anabolic steroids to build lean muscle mass
    • Free worldwide shipping
    • Formulated by bodybuilders to build muscle efficiently.

If you’re looking to boost your lean muscle mass and strength levels quickly, D-Bal Max is a powerful muscle-building supplement that can help you achieve your fitness goals. Developed with athletes in mind, these pre- and post-workout supplements are designed to increase testosterone production, which helps stimulate muscle protein synthesis, resulting in larger, stronger muscles.

But that’s not all. D-Bal Max also enhances endurance and overall training performance, enabling you to push yourself to the limit and see faster results. Its energy-boosting properties help you train longer without fatigue, making it ideal for serious bodybuilders and fitness enthusiasts.

But the benefits don’t stop there. By enhancing cognitive function, the D-Bal Max muscle gain supplement supports brain function during workouts, enabling you to stay mentally focused and alert even during the most intense training sessions.

Produced by Wolfson Brands (UK) Limited, a highly reputable company in the nutritional supplements market, D-Bal Max protein supplements are formulated with natural ingredients and are free from harmful side effects.

Thus, with an increased lean muscle mass, you will look and feel more attractive, boosting your confidence and self-esteem.

Benefits Of D-Bal Max

Supports Muscle Growth: D-Bal MAX protein supplements enhance nitrogen retention in the body. Nitrogen is a crucial component of amino acids, which are the building blocks of protein. By increasing nitrogen retention, D-Bal MAX muscle mass supplements enable your body to store more protein, which can fuel your workouts, helping you build more muscle mass.

This supplement is a true muscle-building powerhouse, providing your body with the amino acids and nutrients to support optimal muscle growth. The whey protein complex in D-Bal MAX is also a crucial component of its muscle-building power.

This high-quality protein source boasts a high biological value rating, meaning that it is easily absorbed by the body and can be used to build and repair muscle tissue. Whey protein supplements like D-Bal are also rich in essential amino acids critical for muscle growth and recovery.

Supports Fat-Burning: D-Bal MAX is not just any ordinary supplement that promises to help you build muscle. It is a powerhouse of nutrients, carefully selected to provide the perfect blend of vitamins, minerals, and proteins for rapid muscle gain. But that’s not all – D-Bal MAX goes beyond muscle gain and helps you burn fat faster, thanks to its ability to increase metabolism and boost digestive health.

Unlike anabolic steroids with their side effects, Whey protein supplements like D-Bal MAX are a safer alternative that gives you the same rapid muscle gain results and helps maintain muscle growth.

It is loaded with whey protein, giving you the energy and strength to push yourself harder during workouts. In addition, D-Bal MAX has been formulated to enhance your testosterone levels, which is crucial for muscle growth.

With regular intake of D-Bal MAX and a healthy diet, you will experience rapid muscle gains and a surge of energy in your body. You may lift heavier weights, do more repetitions, and take your workouts to the next level. And as your muscles grow, your body will naturally burn more fat, helping you achieve that lean, ripped physique you’ve always wanted.

XWerks Rise

  • Ingredients: Zinc, Tongkat Ali, shilajit, BioPerine, boron.
  • Pricing: $49
  • Money-Back Guarantee: 30-day
  • What Sets XWerks Rise Apart:
    • Natural muscle strength booster
    • Independent reviews supporting Rise assistance to improve muscle soreness by balancing protein synthesis
    • Money-back guarantee.

XWerks Rise is a revolutionary product designed to optimize and balance hormone levels naturally to feel more energized, confident, and stronger. As we age, our body’s hormone production may decline, resulting in decreased testosterone levels and increased cortisol and estrogen levels.

The stress we face daily can further accelerate this process. However, with RISE muscle mass enhancer, you can combat these hormone imbalances with its unique blend of all-natural, proven ingredients that synergize to bring you back to your former self, or maybe even better.

RISE lean body mass booster is not just any ordinary testosterone booster; it is a comprehensive formula that helps increase testosterone levels and regulates cortisol and estrogen to healthy, optimized levels.

With its powerful ingredients, RISE muscle growth supplements can help increase energy, improve focus and concentration, and enhance overall athletic performance.

Benefits Of XWerks Rise

It can Raise Testosterone And Boost Libido: Xwerks Rise is the best muscle growth supplement with a powerful ingredient known as Tongkat Ali or Longjack. Tongkat Ali is rich in flavonoids, alkaloids, and antioxidants, which have been shown to boost testosterone levels and enhance libido.

With Xwerks Rise, you can experience the benefits of this natural ingredient to help optimize your hormone levels, promote muscle growth and improve your overall well-being.

Can Strengthen Bones: Boron, a micronutrient that helps stimulate muscle protein synthesis, is a trace mineral in Rise’s formulation. By incorporating this essential element, muscle gain supplements from Rise can help to increase muscle mass and accelerate metabolism in the body.

Transparent Labs Mass Gainer

  • Ingredients: Calcium, iron, potassium, dietary fiber, protein, vitamin D, creatine monohydrate, MCT, and more.
  • Pricing: $76.99
  • Money-Back Guarantee: 30-day
  • What Sets Mass Gainer Apart:
    • No artificial sweeteners or preservatives to stimulate protein synthesis
    • 3rd party lab tested to help gain muscle naturally
    • Gluten-free formula to increase muscle mass.

Transform your physique and achieve your fitness goals with Transparent Labs Mass Gainer, an all-in-one muscle gains supplement that delivers the perfect balance of muscle-building macro-nutrients and safe weight gain.

Whether you’re a fitness enthusiast seeking to supplement your meals or an athlete looking to pair it with your workout, the Mass Gainer muscle gains have you covered. With many powerful macro-nutrients, this supplement boosts muscle growth and protects healthy muscle tissue.

The ProteinSeries Mass Gainer provides one of the purest and most efficacious formulas for building muscle, boosting muscle strength, and gaining weight. Each serving packs a whopping 53 grams of protein to increase lean muscle mass.

Benefits Of Transparent Labs Mass Gainer

Protein is a vital component for muscle growth and repair, and whey protein has proven to be an excellent source of this macronutrient. However, the benefits of consuming protein-rich foods can be maximized when combined with sufficient carbohydrates and fats, which provide the necessary energy to fuel muscle growth and optimize physical performance.

This is where Transparent Labs’ Mass Gainer comes in – with a macronutrient-complete formula that is designed to support lean muscle growth, promote muscle recovery, and increase muscle mass.

In addition to the essential macronutrients, the Mass Gainer also contains creatine, a popular supplement shown to aid in rapid muscle growth and performance. It has been shown to increase strength levels quickly, enhancing muscle gains due to progressive overload.

Overall, the Mass Gainer from Transparent Labs provides a comprehensive blend of macronutrients and supplements for optimal athletic performance and lean muscle growth. With its carefully designed formula and inclusion of creatine, this supplement offers a powerful tool for individuals serious about achieving their fitness goals.

CrazyBulk Intensive Pre-Train

  • Ingredients: Beta-alanine, citrulline, amino acids, Ashwagandha, vitamins, and more.
  • Pricing: $59.99
  • Money-Back Guarantee: 60-day
  • What Sets Intensive Pre-Train Apart:
    • 3 flavored protein powder
    • The all-vegetarian formula for building muscle mass
    • Legal in all countries and can be added to any healthy diet program.

Suppose you’re serious about building muscle and improving your overall fitness. In that case, you may have come across Crazy Bulk, a company that offers a range of supplements designed to help you achieve your fitness goals.

One of the products in their lineup is Intensive Pre-Train. This pre-workout supplement promises to help you prepare for the most intense workout sessions without any of the adverse side effects associated with natural steroids.

So, what exactly does Intensive Pre-Train do? This muscle supplement contains a powerful blend of 19 ingredients that increase energy levels, improve focus, and reduce fatigue. Doing so helps you stay motivated and consistent in your training, regardless of how intense your workout may be.

Of course, it’s not just bodybuilders who can benefit from Intensive Pre-Train muscle growth supplements. Anyone serious about their fitness routine, from fitness enthusiasts to athletes training for competition, can reap the rewards of this powerful supplement.

By providing you with the athletic agility, energy, focus, and motivational drive you need to excel in your sport or fitness routine, Intensive Pre-Train supplements for muscle growth can help you achieve your fitness goals faster and with greater ease.

Benefits Of CrazyBulk Intensive Pre-Train

Can Support Speedy Recovery From Muscle Soreness: Pre-Train muscle-building supplements contain citrulline malate, a potent amino acid shown to provide a range of benefits for athletes and fitness enthusiasts. One of the key benefits of this amino acid is its ability to promote speedy recovery after intense workouts. This is because citrulline malate helps to reduce muscle soreness and fatigue, allowing you to train harder and recover faster.

In addition to its recovery benefits, citrulline malate enhances athlete performance. This amino acid works by strengthening the blood vessels and managing the supply of oxygen in the body. By doing so, it can improve blood circulation, which in turn supports better performance during training sessions.

Can Boost Muscle Development: Vitamin C has long been essential for maintaining good health and vitality. Recent research has shown that it may also be critical in promoting muscle mass and supporting a healthy immune system, especially for older people. This potent vitamin is essential for producing collagen, which is necessary for the growth and repair of muscle tissue and the faster healing of wounds.

In addition to its muscle-building benefits, vitamin C has also been found to help improve balance, stability, and bone density. These factors are critical for maintaining mobility and preventing falls and injuries, which can be especially important for older individuals.

Another ingredient found in the workout supplements from CrazyBulk to help promote energy levels and reduce fatigue is thiamine. This means that thiamine can help to increase energy levels and reduce the risk of fatigue, making it an ideal ingredient for anyone looking to improve their performance during workouts or daily activities.

Combining these two powerful ingredients allows individuals to enjoy various health benefits, including improved muscle mass, a healthy immune system, faster wound healing, better balance and stability, and increased energy levels. This is particularly important for older individuals experiencing age-related declines in their health and performance.

CrazyBulk Tri-Protein

  • Ingredients: Whey protein isolate, whey protein concentrate, micellar casein, milk protein, calcium caseinate, whey protein hydros-late, digezyme.
  • Pricing: $48.99
  • Money-Back Guarantee: 60-day
  • What Sets Tri-Protein Apart:
    • 3 flavored protein powder
    • GMO-free product for muscle recovery
    • Natural supplement to build muscle.

If you’re looking for a high-quality protein powder that can help you achieve your fitness goals, then 100% Tri-Protein by Crazy Nutrition is an excellent option to consider. This protein powder contains six different types of proteins released in three distinct phases, providing a sustained release of nutrients that can support muscle growth, improve recovery, and promote feelings of satiety.

The “tri” in 100% Tri-Protein refers to the three phases into which the proteins are broken down. In the first phase, your body absorbs whey protein hydrolysate and whey protein isolate, which provide immediate muscle fuel to aid in faster recovery from strenuous workouts. These proteins are quickly absorbed and can help to jumpstart the muscle-building process.

In the second phase, milk protein concentrate, whey protein concentrate, and a digestive enzyme blend are released. These proteins are slower to digest and are, therefore, ideal for muscle-building mass over a more extended period. The digestive enzyme blend also helps to prevent bloating and discomfort, making it easier to consume this protein powder regularly.

Finally, the third phase sees the absorption of micellar casein and calcium caseinate, which are slow-digesting proteins that can help to suppress appetite and promote feelings of fullness. This can be especially helpful for those struggling with cravings or weight management.

Overall, 100% Tri-Protein workout supplements are excellent protein powder that provides a sustained release of nutrients over hours rather than all at once. This muscle-building supplement can help to support muscle growth, improve recovery, and promote feelings of satiety, making it an ideal choice for anyone looking to improve their fitness and overall health.

Benefits Of CrazyBulk Tri-Protein

Can Help To Gain Muscle Faster: Tri-Protein is a premium protein supplement that harnesses the benefits of six high-quality whey proteins to support muscle growth and development in those who take it regularly. In addition to supporting muscle growth and development, Tri-Protein muscle-building supplements also aid in protein synthesis and promote faster recovery after intense workouts, allowing you to push yourself harder and achieve your fitness goals faster.

And these supplements for muscle growth are designed to help you lose weight without sacrificing muscle mass. Tri-Protein supplements can be ideal for those looking to build a leaner, more toned physique.

Can Boost Metabolism: Tri-Protein supplements are potent and innovative products that pack a powerful punch when it comes to boosting your metabolism and energy levels.

One of the standout benefits of Tri-Protein muscle-building supplements is their ability to enhance your metabolic rate. By stimulating your metabolism, this protein supplement can help you burn calories more efficiently, even when you’re not actively working out.

And when combined with regular exercise and a normal diet, it can help you achieve your fitness goals faster and more effectively.

CrazyBulk Ultimate CRN-5

  • Ingredients: Creatine monohydrate, Creatine Hydrochloride (HCL), Creatine Ethyl Ester, Tri-Creatine Malate, Creatine Citrate Pyruvate, and more.
  • Pricing: $44.99
  • Money-Back Guarantee: 60-day

Crazy Nutrition Ultimate CRN-5 is a top-of-the-line muscle-builder supplement that promises to help you achieve your desired body physique with its advanced formula that contains five premium creatine ingredients and electrolytes.

Being one of the best supplements for muscle, it can provide optimal hydration to promote muscle building and energy output during strenuous workouts without causing bloating or gas.

Unlike other muscle-builder supplements, the gluten-free and vegan-friendly Ultimate CRN-5 by Crazy Bulk is unique and offers faster recovery by reducing lactic acid buildup in muscles. With the support of experts such as trainers, nutritionists, and medical professionals worldwide, the Ultimate CRN-5 dietary supplement offers a safe, natural alternative to other muscle-building supplements on the market.

Benefits Of CrazyBulk Ultimate CRN-5

Promotes Muscle Growth: Ultimate CRN-5 is packed with creatines and electrolytes to fuel muscle growth through protein synthesis and keep you hydrated for peak workout performance.

Enhance Performance: Ultimate CRN-5 muscle-building supplement preserves muscle mass while enhancing performance for a worry-free cutting experience.

Boost Focus: Ultimate CRN-5 replenishes crucial electrolytes to maintain optimal hydration levels, helping prevent muscle fatigue and keeping your attention and focus sharp.

HyperGH 14X

  • Ingredients: L-Glutamine, L-Arginine, L-Glycine, L-Valine, L-Lysine, L-Ornithine, Tribulus Terrestris, Astragalus, colostrum, GABA, and more.
  • Pricing: $69.95
  • Money-Back Guarantee: 67-day
  • What Sets HyperGH 14X Apart:
    • 100% legal best muscle-building pills
    • Manufactured in FDA-approved and cGMP-compliant facilities to build healthy muscle tissue
    • 24/7 support care.

HyperGH 14X is among the best to promote the natural release of Human Growth Hormone (HGH). This helps increase muscle growth and reduce aging signs.

These muscle supplements are specially formulated with clinically tested and legal ingredients that stimulate the production of HGH without causing any negative impact on your health or resulting in painful injections like the synthetic HGH in the market.

Unlike other HGH supplements, HyperGH 14X muscle supplements feature an advanced dosing system that works with your body’s natural circadian rhythm, boosting your Exercise-Induced Growth Hormone Response (EIGR) to increase the daily pulse releases of HGH safely, naturally, and legally.

The formula is specifically designed for bodybuilders who want to achieve their muscle-building goals and those who want to experience the broad-spectrum anti-aging benefits of HGH.

Benefits Of HyperGH 14X

May Help With Muscle Repair: HyperGH 14X muscle supplement contains L-Glutamine, which can aid in muscle repair during resistance training while boosting protein synthesis and T and HGH levels.

Can Boost Sleep Quality: The benefits of HyperGH 14X muscle builder supplements extend beyond muscle-building and anti-aging. This supplement may also improve sleep quality, which is crucial for optimal recovery and overall health.

May Support All-Round Health Benefits: HyperGH 14X is the best muscle-building pill with ingredients shown to support liver, prostate, and heart health. One of the critical benefits of HyperGH 14X muscle growth supplements is their ability to stimulate the natural secretion of growth hormones in the body, which can promote muscle growth, improve bone density, and reduce body fat.

Moreover, some of the ingredients in HyperGH 14X muscle supplements, such as GABA, may have a soothing effect on the brain, helping to reduce stress and anxiety.

Cellucor C4 Extreme

  • Ingredients: Beta-Alanine, caffeine, creatine nitrate, citrulline, N-Acetyl-L-Tyrosine, Huperzine A.
  • Pricing: $34.99
  • Money-Back Guarantee: 60-day
  • What Sets Cellucor C4 Extreme Apart:
    • Free US shipping
    • Natural Flavours
    • Clean formula to build muscle.

Cellucor, a US-based sports nutrition brand located in Austin, Texas, and a subsidiary of Nutrabolt, has formulated the C4 Extreme muscle supplements to deliver an explosive pre-workout performance with its clean and precise formula, enriched with 200mg of caffeine.

With its variety of five flavors, C4 Extreme supplements for muscle growth support sustained energy, muscle development, and endurance to power through your workout routine.

Benefits Of Cellucor C4 Extreme

Can Boost Energy And Focus: C4 Extreme is the ultimate pre-workout supplement designed to elevate your training. This powerful blend delivers extreme energy and focuses on helping you crush your fitness goals like never before.

Whether you want to improve your endurance, increase your strength, or push your limits, C4 Extreme is the perfect choice to take your training to the next level.

Can Boost Athletic Performance: Get the ultimate performance with the support of the C4 Extreme muscle-building supplement.

This powerful pre-workout supplement can enhance strength and performance thanks to the advanced Creatine Nitrate (NO3-T) and NitraMax (NO3-C) technology.

The Standards Used to Rank the Best Muscle-Building Supplements

Here are a few of the factors we considered before ranking the best muscle-builder supplements in this review:

Price Value

Our selection of the best muscle-building supplements includes top-performing products and emphasizes cost-effectiveness. We have curated a list of pre and post-workout supplements that are both budget-friendly and effective in increasing muscle mass, offering you the best value for your money.

Natural And Safe Ingredients

We understand the importance of using natural ingredients for muscle-building supplements as customers often prefer them for their safety and lack of adverse health effects. With this in mind, we have carefully curated a list of the best muscle-building supplements made with natural elements with no reported harmful side effects, allowing for easy and safe muscle mass gain.

Clinically Tested Supplements For Muscle Growth

Our selection of muscle supplements in this review undergoes third-party testing and is backed by scientific research, ensuring their reliability and efficacy in promoting health and fitness.

Reported Health Benefits

The best muscle-building supplements in this list claim to provide health benefits and have numerous positive customer reviews to support their effectiveness. By incorporating these supplements for muscle growth into your post-workout routine, you can achieve your fitness goals quickly and confidently.

Does Science Back Ingredients in The Best Muscle-Building Supplements?

If you’re serious about building muscle, you want to ensure that you’re investing in products that have been scientifically tested and proven to work.

In this section, we’ll explore some of the most popular muscle-building supplements today and determine whether they’re backed by scientific evidence. So before reaching for your next supplement bottle, let’s examine whether these products can help enhance your gains.


Beta-alanine combines with histidine to form carnosine, stored in your skeletal muscle tissue. Carnosine helps to buffer the muscle pH during high-intensity exercise, slowing down lactic acid accumulation – which causes pain and fatigue. This results in improved overall performance and better training results.

Many studies have been conducted regarding beta-alanine and its effect on muscle growth. One study published by the Journal of Strength & Conditioning Research assessed beta-alanine supplements’ impact on athletes’ body composition changes over eight weeks of routine practice. The participants who received beta-alanine had more significant muscle mass gains than those who did not use it.

Another study by Amino acids journal also confirmed that daily supplementation with 4 grams of beta-alanine for eight weeks improves physical working capacity at fatigue threshold (PWCFT), a parameter predictive of endurance performance, suggesting that beta-alanine supplementation might positively affect endurance exercise capacity.

Moreover, as mentioned earlier, consuming beta-alanine leads to higher levels of carnosine accumulation in muscles which can help delay fatigue during intense workouts. Helping you train longer than before makes sure your muscles get exposed to stress for longer, leading to more significant gains.

Beta-alanine supplements have also shown effects on improving power output by increasing anaerobic metabolism allowing for faster recruitment of fast-twitch muscle fibers.

Whey Protein Isolate

In simple terms, a whey protein isolate is a form of whey protein that has gone through further processing, thus separating almost all of the carbohydrates and fat, leaving only a very high concentration of protein content. Compared to other forms of whey, such as whey concentrate or casein powder, whey protein isolate absorbs much faster into the muscles due to its high-efficiency level.

When you exercise, your muscle breakdown occurs at the cellular level while your body needs nutrient-dense proteins to support repair and growth. Whey protein isolate provides one of the purest forms of digestible protein for supporting muscle recovery post-workout.

The human body then utilizes this highly absorbent substance by breaking down the amino acids necessary for muscular repair.

Much research is on how excellent whey protein isolate can boost muscle growth and repair muscles after vigorous activity.

A 2017 Danish study published in Nutrition & Metabolism showed that consuming a significant amount (30 grams) following resistance-based exercise increased muscle synthesis over 24 hours emphasizing quicker recovery time post-physical exertion.

Another recent paper by Dr. Michael J Ormsbee found that adding two servings of whey protein isolate and other amino acid supplements per day – each containing ~20 grams- led to more incredible body fat-free mass gains.

Creatine Monohydrate

Creatine is a natural substance in the body, particularly in skeletal muscle cells. Creatine Monohydrate is an artificially produced form of creatine popularly used as a workout supplement because it provides energy to muscles, allowing them to work harder and longer during exercise.

Creatine monohydrate increases cell energy production by forming adenosine triphosphate (ATP) molecules responsible for supplying energy to muscle contractions.

By increasing ATP production, creatine enhances your ability to perform more repetitions with heavier weights during resistance exercises, improving overall athletic performance. This leads to increased loads being lifted over time and increased gains in muscle mass overall.

A meta-analysis of 10 randomized controlled trials (RCTs) published between January 1985 and December 2019 studied the effects of creatine supplementation on weight-lifting exercises’ maximal strength.

The results showed that daily supplementation with creatine monohydrate for as little as five days could significantly increase maximum weight-lifting efforts by about 1-2 kg (or about 2-4 pounds). Another study found that creatine monohydrate supplementation was effective even among elderly participants aged up to 76.

Branched-Chain Amino Acids

Branched-Chain Amino Acids (BCAAs) are three essential amino acids: valine, leucine, and isoleucine. Essential amino acids cannot be produced by the body and can only be obtained through the diet. BCAAs are abundant in meat, eggs, dairy products, and legumes.

One of the primary functions of Branched-Chain Amino Acids is to stimulate muscle protein synthesis. The amino acid leucine is vital in activating specific signaling pathways that promote muscle protein synthesis. Additionally, BCAA reduces muscle protein breakdown during exercise by decreasing the activity of proteolytic enzymes.

Several studies have examined the effect of Branched-Chain Amino Acids supplementation on muscle growth and function. One study found that individuals who consumed a Branched-Chain Amino Acids supplement before resistance exercise had a more significant increase in muscle strength and hypertrophy than those who did not take a supplement.

Another study showed that athletes supplemented with Branched-Chain Amino Acids for ten weeks had increased lean mass and reduced body fat compared to athletes who took a placebo.

Branched-Chain Amino Acids may also promote the formation of new muscle cells known as myoblasts. Several animal studies have demonstrated that leucine-rich diets can enhance the differentiation of myoblasts into mature muscle cells.

Citrulline Malate

Citrulline Malate is an amino acid compound comprising citrulline (an amino acid found in watermelon) and malate (a salt compound derived from malic acid). It’s commonly used as a pre-workout supplement to help improve athletic performance.

One of the critical benefits of Citrulline Malate is its ability to increase nitric oxide levels in the body. Nitric oxide helps to relax blood vessels, which increases blood flow and oxygen delivery to muscles during exercise. This increased blood flow can help athletes work out longer and recover quickly.

In addition, Citrulline Malate has been shown to help reduce muscle soreness after exercise. This can be particularly beneficial for those just starting a new workout routine or increasing their intensity.

A 2010 study published in the “Journal of Strength & Conditioning Research” found that subjects who took Citrulline Malate before weight-lifting experienced less muscle fatigue and improved muscular endurance than those who took a placebo.

Another study published in “Nutrition” in 2016 found that Citrulline Malate supplementation helped increase strength training performance while reducing muscle soreness.


Ashwagandha, or Withania Somnifera or Indian ginseng, is an adaptogenic herb used in Ayurvedic medicine for over 3,000 years to boost energy levels, reduce stress and anxiety, and promote overall wellness. The roots of this herb contain bioactive compounds that have numerous benefits for the human body.

Studies have shown that Ashwagandha can positively impact muscle growth by increasing testosterone levels in men. Testosterone is a hormone that plays a crucial role in building muscle mass and strength.

Studies have also shown that Ashwagandha can positively impact muscle growth by increasing testosterone levels in men. Testosterone is a hormone that plays a crucial role in building muscle mass and strength.

One study on healthy young men found that taking ashwagandha supplements significantly increased muscle mass and strength compared to the control group who did not take any supplements.

Another way Ashwagandha helps with muscle growth is by promoting protein synthesis. Protein synthesis occurs when new proteins are formed from amino acids inside our body’s cells. By enabling this process, Ashwagandha may help increase lean body mass over time.

In addition to boosting existing muscles’ size, studies suggest that Ashwagandha can help form new muscle cells (myoblasts). One study on mice demonstrated that supplementing with Ashwagandha increased myoblast differentiation into mature skeletal muscle fibers.


Several studies have shown the positive effects of fenugreek on muscle growth. In one study, participants who took a fenugreek supplement and resistance training showed increased muscle strength compared to those who only did resistance training without supplementation.

Another study found that participants who took a fenugreek supplement had higher testosterone levels than those who did not.

One of the reasons why fenugreek may benefit muscle growth is because it contains compounds called saponins. These saponins are believed to help increase testosterone production, crucial in building and maintaining muscles.

Additionally, fenugreek is rich in protein and essential amino acids such as leucine, which are necessary for muscle growth and repair. Leucine also triggers a pathway known as mTOR, which stimulates protein synthesis and helps build more muscle fibers.

FAQs About Muscle-Building Supplements

Q: Does Whey Protein Powder Have Any Side Effects?

A: One of the most commonly reported side effects of whey protein powder is gastrointestinal discomfort. This can include bloating, gas, cramping, and diarrhea.

These symptoms are typically mild and may be more common in those who have lactose intolerance or other digestive issues. To minimize these symptoms, try starting with a small dose of whey protein powder and gradually increasing it over time as your body becomes accustomed to it.

While rare, some people may experience an allergic reaction when consuming whey protein powder.

Q: Why Is Beta Alanine Often Included In The Best Muscle Mass Supplements?

A: Beta-alanine is an amino acid that combines with another amino acid, histidine, to form carnosine – a dipeptide that helps regulate muscle pH levels.

When we exercise, our muscles produce lactic acid, which can lead to a decrease in pH and increase the feeling of fatigue. Carnosine works by buffering against this change in pH, ultimately leading to less fatigue during workouts and potentially increased endurance.

While beta-alanine doesn’t directly contribute to building muscle mass, its ability to reduce fatigue and increase endurance can translate into longer, more intense workout sessions. This can lead to an increase in overall training volume which has been shown to positively affect both muscle hypertrophy (growth) and strength gains.

The most common side effect of taking beta-alanine is a tingling sensation or “flushing” feeling – known as paresthesia – that often occurs shortly after ingestion. This is usually harmless and goes away relatively quickly.

Q: What Causes Muscle Breakdown?

A: A primary reason for muscle breakdown is inactivity. They deteriorate when inactive or don’t engage in physical activity, leading to muscle mass loss and weakness. To prevent this, it’s essential to stay active and exercise regularly.

As we age, our bodies naturally lose muscle mass and strength. This process, called sarcopenia, typically begins around age 30 and progresses gradually. Proper nutrition and regular exercising through resistance training (lifting weights), balance work (yoga), and low-impact cardio exercises can slow down its progress.

A lack of proper nutrition can also cause muscle breakdown. Your muscles need protein, carbohydrates, and essential vitamins to maintain strength and size. A diet high in herbal supplements like Ashwagandha or whey protein powder should always be combined with whole foods that provide sufficient macronutrients.

Q: Can You Boost Muscle Growth Through Exercise?

A: Exercise stimulates the body’s natural muscle-building processes by creating microscopic muscle tears. These tears then repair themselves during recovery with increased strength and size. However, exercise alone may not be enough to achieve significant muscle growth without a proper diet consisting of adequate protein and healthy carbohydrates.

Resistance training exercises such as weight lifting, pull-ups, push-ups, and squats are among the best activities for boosting muscle growth. Focusing on compound movements that activate multiple muscles at once rather than isolated exercises that only work specific muscles is essential.

The Best Muscle-Building Supplements in 2023 Conclusion

Muscle growth supplements can be effective in the short term, but whether they can be relied upon for long-term benefits is debatable.

While some supplements may offer benefits like increased muscle mass, improved recovery time, and enhanced performance, they may not provide sustained results without consistent training and a balanced diet.

It is important to remember that dietary supplements should not replace a healthy lifestyle but rather complement it.

Try a top muscle-building supplement above today!

Also Read: Best Protein Supplements: Top Protein Powder Shakes for Muscle Gain

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